Dual control of meiotic crossover patterning
WebFor the past few years, my research projects have been focused on studying various aspects of worm reproduction, in particular how the network of events, including homolog pairing, meiotic recombination and chromosome reorganization following crossover designation that are constitutive of this complex program is coordinated to ensure … WebOct 24, 2024 · Joint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage. Nature Communications , 2024; 13 (1) DOI: 10.1038/s41467-022-33472-w Cite This Page :
Dual control of meiotic crossover patterning
Did you know?
WebFeb 6, 2015 · Figure 1. Meiotic crossover (chiasma) patterns. (A) Meiosis comprises 2 successive rounds of chromosome segregation.At Meiosis I, homologous chromosomes (red and black) segregate to opposite poles. The segregating chromosomes are connected by the combined effects of a CO between one sister of each homolog and links between … WebDOI: 10.4161/15384101.2014.991185 Abstract During meiosis, crossover recombination is tightly regulated. A spatial patterning phenomenon known as interference ensures that …
WebJul 13, 2024 · Given the difference of 6.9 crossovers between the two subpopulations at the ends of the scale, we looked at each subpopulation’s recombination landscape to understand the nature of this increase in crossover number (Tukey’s HSD test, P = 0.0068, Fig. S3).Interestingly, comparing recombination rates (cM Mb −1) between the two most … WebApr 11, 2024 · Meiotic crossovers/chiasmata are not randomly distributed and strictly controlled. The mechanisms behind crossover (CO) patterning remain largely unknown. In Allium cepa, as in the vast majority of plants and animals, COs predominantly occur in the distal 2/3 of the chromosome arm, while in Allium fistulosum they are strictly localized in …
WebConference Description. The Gordon Research Seminar on Meiosis is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas. The primary focus of this meeting is to explore the molecular mechanisms by which diploid progenitor ... WebJul 25, 2024 · Aberrant crossover patterns, e.g., absence of the obligatory crossover, are the leading cause of infertility, miscarriage, and congenital disease. Therefore, crossover patterns have to be tightly controlled. During meiosis, loop/axis organized chromosomes provide the structural basis and regulatory machinery for crossover patterning.
WebApr 23, 2024 · We demonstrate that this model is capable of quantitatively reproducing and predicting zyp1 experimental crossover patterning and HEI10 foci intensity data. Additionally, we find that a model combining both SC- and nucleoplasm-mediated coarsening can explain crossover patterning in wild-type Arabidopsis and in pch2 …
WebDec 1, 2024 · Chromosome Organization. A series of crucial events takes place during meiotic prophase I, including the formation and repair of DSBs, and the pairing, synapsis, and recombination between homologous chromosomes (Zickler and Kleckner, 1999; Handel and Schimenti, 2010).Meiotic DSB formation is catalyzed by the meiosis-specific … main line health lawrence park radiologyWebMar 28, 2024 · Dynamic control of the meiotic recombination landscape. Steiner highlights a study by Protacio et al., which has identified molecular mechanisms underlying the plasticity of meiotic recombination ... main line health labs near meWebOct 12, 2024 · It is shown that overexpression of the Arabidopsis pro-crossover protein HEI10 increases crossovers but maintains some interference and sexual dimorphism, and advocates a CO patterning model via coarsening through the diffusion of HEI 10 along the synaptonemal complex. Meiotic crossovers are limited in number and are prevented … main line health lab locationsWebMay 11, 2024 · Here, we show that overexpression of the ZMM protein HEI10 increases COs and reduces crossover interference but maintains sexual dimorphism; shorter axes length in female meiosis is still associated with fewer COs and stronger interference than … main line health lawrence park labWebJan 23, 2016 · To ensure tethering of homologous chromosomes during MI, most eukaryotes possess a sophisticated mechanism to control meiotic recombination outcomes. Central to this “crossover control” mechanism is a decision to direct a DSB to either a crossover or noncrossover fate (Bishop and Zickler 2004) (Fig. 6.1). main line health lawrence park broomallWeb31 for CO patterning in many eukaryotes. 32 . Introduction 33 A hallmark of sexual reproduction is the shuffling of homologous chromosomes by 34 meiotic crossovers … main line health lawrence park urgent careWebJoint control of meiotic crossover patterning by the synaptonemal complex and HEI10 dosage Stéphanie Durand 1,4, Qichao Lian 1,4,JuliJing1,4,MarcelErnst2, Mathilde … main line health labs broomall